Sheffield United take on West Bromwich Albion at Bramall Lane in the Sky Bet Championship. Separated by a single point near the top, a win for either side could be vital here.
Livingston face Hearts in the Ladbrokes Premiership at the Tony Macaroni Arena. Hearts ended a run of seven games without a win with a 1-0 victory over Motherwell last time out.
Manchester City take on Everton at the Etihad Stadium in the Premier League. City will be looking to respond after suffering a first league defeat of the season at Chelsea last week.
Bristol City host Norwich City at Ashton Gate in the Sky Bet Championship. The Canaries are looking to make it 10 league games unbeaten here as they look to firm their grip on top spot.
Bottom-of-the-table Fulham play host to in-form West Ham at Craven Cottage in the Premier League. The last meeting between the two London rivals ended 2-1 to Fulham back in 2014.
Hibernian welcome Celtic to Easter Road in the SPFL Ladbrokes Premiership. Celtic were 4-2 winners when these sides met earlier in the season.
Southampton meet Arsenal at St. Mary's Stadium in the Premier League. This is Saints' first home game under new boss Ralph Hasenhuttl, while Arsenal are unbeaten in the league since August.
Old rivals meet at Anfield as Liverpool host Manchester United in the Premier League. Jurgen Klopp's side head into this still unbeaten in the league - can Mourinho's men stop them?